Background and Objective: Prejudice against sexual diversity is one of the faces of Gender-based Violence. Lesbians, gays, bisexuals, and other sexual minorities (LGB+) are victimized all over the world and Brazil is considered the most violent country against this population. However, there is a lack of data on this condition in the country. Thus, the aim of this study was to analyze the association between self-reported sexual orientation and violence in the Brazilian population. methods Cross-sectional epidemiological study using the 2019 National Health Survey database. Total violence and its subtypes (psychological, physical, and sexual) in the last 12 months were analyzed. Prevalence and Adjusted Odds Ratio (ORaj) by age group were estimated, with their respective 95% confidence intervals (95%CI), according to self-reported sexual orientation of the population over 18 years in Brazil. Results: The Brazilian population report themselves mostly as heterosexual (94.75%), and 1.89% declaring themselves LGB+. The prevalence of total violence in Brazil was 18.27%, being lower among heterosexual men (16.35%; 95%CI: 15.62-17.11), while LGB+ women had the highest prevalence (42,51%; 95%CI: 36.26-49.01). The LGB+ population was more than twice as likely to experience any type of violence (ORaj: 2.52; 95%CI: 2.08-3.07). LGB+ women were more than three times more likely to experience physical violence compared to heterosexual women (ORaj: 3.18; 95%CI: 2.09-4.83). Meanwhile, LGB+ men were almost eight times more likely to experience sexual violence than heterosexual men (ORaj: 7,76; 95%CI: 3.38-17.81). Conclusions: Violence against the LGB+ population was highly prevalent in the country. LGB+ women had the highest prevalence of all subtypes of violence and heterosexual men the lowest. Public Policies aimed at this population are necessary to address prejudice against sexual diversity and guarantee the rights of non-heterosexual people. Keywords: sexual and gender minorities, sexual discrimination, gender-based violence, health surveys