Background: The purpose of this study was to assess knowledge, attitudes and practices (KAP) among people living with HIV (PLWH) about general vaccination and their trust on the Italian National Health Service (NHS). Methods: A cross-sectional study was conducted by administering questionnaires to 160 patients followed by Amedeo di Savoia Hospital in Turin. Statistical analyses were performed to describe the samples vaccination status, its willingness to get vaccinated, the perception of the risk and the severity of infections preventable with vaccination and its trust on the Italian NHS. Results: Means for vaccination status, vaccination intention, perceived risk of infection, and disease severity were calculated by grouping infections into two sets: the first was formed by sexually transmitted infections and the second by the remaining. Percentages of the two groups do not differ in being already vaccinated, willingness to be vaccinated (if not already immune), and perceived low risk of infection (51,16%, 14,76%, 75,65% for the former and 48,58%, 20,61%, 76,33% for the latter, respectively) but in perceived high risk of severity (81,7% vs 65,25%). Regarding patients opinion of the Italian NHS, interesting results were that while 95.63% of the sample believe the information provided by healthcare professionals (HCPs) and 93.08% believe that they are up-to-date on vaccines, 33.33% of the sample believe that HCPs do not give enough information about the risks related to vaccination, 40.25% believe that patients are judged by HCPs in case of unwillingness to get vaccinated and 19.50% believe that HCPs have financial interests in vaccinating. Conclusions: Some HIV+ patients may be hesitant to be vaccinated or believe that some infectious diseases are not dangerous. Furthermore, there is some criticality about their trust on the Italian NHS.