Background: The walkability of the urban environment is the facility of walking around the urban area. This includes the availability of safe and well-designed roads, air quality, green spaces, and cycling infrastructure among other features of the environment. Walking is proven to improve health, but not all urban spaces are equally walkable. Aim: To explore the impact of the urban environment walkability on the prevalence and development of chronic non-communicable diseases (NCDs). Methods: A scoping review will be conducted following the standards of the Joanna Brigg Institute and PCC framework. The results will be reported in accordance with the PRISMA-ScR statement. The review will contain articles published between 2001 and 2020 in the Medline and Embase databases. Systematic reviews, ecological studies, clinical trials, quasi-experimental and observational studies that meet the eligibility criteria will be included. The impact on outcomes such as physical activity, obesity, blood pressure, hypertension, diabetes, and others like mental health, quality of life, and healthy behaviors will be explored. Expected results: This study will help to identify how walkable environments are associated with NCDs. Furthermore, emphasize how the importance of considering indicators of the walkability of the urban environment when planning, designing and implementing public health interventions. This scoping review will identify the feasibility of urban environments to promote physical activity and better health outcomes.