Background and Objective: Sexual and gender minorities have a higher risk of experiencing certain mental and physical health issues compared with cis-gender and heterosexual population. During the past years, there has been a greater recognition by the medical community of the health needs of LGBT+ persons. However, an updated analysis of medical publications about LGBT+ persons has not yet been carried out since 2007. This work was aimed to analyze scientific literature on LGBT+ population considering the 2008-2021 time range. Methods: A literature search was performed in Web of Science database. Bibliometric data from the selected publications were exported and analyzed using R-Studio, Biblioshiny and VOSviewer software. Results: A total of 31039 articles were found. The publications per year have shown rapid growth, going from 1156 articles in 2008 to 4338 in 2021. The most productive author was Mayer K. with 386 articles, who is also the author with most citations (15748) and the highest h-index (56). The USA were the most productive country with 16249 articles, followed by United Kingdom, Canada, Australia, and China. Co-occurrence analysis of the author’s Keywords showed that the most important research focuses were on HIV, sexual transmitted diseases, and sexual identity. Analysis of the thematic map of author’s Keywords revealed that the topics “HIV”, “Men who have sex with men” and “pre-exposure prophylaxis” were of medium importance and development; the topics “sexual orientation”, “lesbian” and “gay” were of high levels of relevance and development, while “transgender”, “gender dysphoria” and “gender identity” were less important compared with other themes or may become new hotspots in the near future. Conclusions: This bibliometric study provides an updated perspective on research about LGBT+ persons and may assist researchers in the further understanding of the fields hotspots, thus facilitating future studies.