Background and Objective: Loneliness is an independent risk factor for stroke in both genders. It is associated with memory and cognitive decline in adults. Our objective was to examine the impact of loneliness on post-stroke functional outcome, memory and depression. Methods: We examined 107 ischemic stroke (IS) survivors (65 males and 42 females), 85 of them were not lonely (NL) and 22 lonely living (LL). The baseline stroke severity was measured by National Institutes of Health Stroke Scale (NIHSS) and the functional outcome - by Barthel Index (BI). All patients were examined twice - at acute IS phase via 10 Words Memory Test (WMT) for short-term (STM), working memory (WM) and 21-Hamilton depression scale (HDS) for severity of depression and at 3rd month after IS via WMT, HDS, Benton Visual Retention Test (BVRT) and Subscales “Information” (for episodic memory – EM) and “Nonpersonal Memory” (for semantic memory – SM) from Blessed Dementia Information Memory Concentration Test. Groups were compared by T-test at 95% confidence level. Data processing was performed by SPSS 24. Results: The stroke severity (NIHSS) of LL and NL groups were similar (p>0.05). NL patients had higher BI than LL (25.1 vs 15.3p.; p=0.0006). LL showed poor STM (4.65 vs 5.63p., p=0.0114) and WM (2.87 vs 4.24p., p=0.0069), compared to NL at acute IS phase. At chronic IS phase LL had poor STM (4.76 vs 5.87p., p=0.0018), WM (3.05 vs 4.48p., p=0.0050), EM (9.91 vs 18.86p, p=0.0041), SM (1.04 vs 2.04; p=0.01) and more total number of errors on BVRT (17.0 vs 13.74, p=0.0120) than NL. Lonely living showed higher HDS results at acute (15.69 vs 19.8p., p=0.0121) but not at chronic IS phase (p>0.05). Conclusions: Loneliness play important role as risk factor for memory decline in elderly post-stroke survivors. It is also associated with acute post-stroke depression.