Background: The prevalence of adolescent female anemia and reproductive age remains alarming. By 2025 globally, it is predicted that there will be an increase in prevalence by more than double by 31.2%. Data on the prevalence of Indonesian adolescents aged 15-24 years has increased, namely in 2013 by 18.4%, an increase of 26.8% in 2018, and this shows that Indonesia is a country with a worsening anemia rate that is difficult to reach the Global nutrition target (anemia) in 2025, namely 14.3%. This study Aims to determine the effect of group WhatsApp-based digital health interventions on improving anemia knowledge in female college students. Methods: The type of research is pre-experimental, using a one-group pretest-posttest approach without a control group. The study sample was 36 female students, using the Purposive sampling technique. Results: The studys results using the paired t-test showed an influence of group WhatsApp-based digital health interventions on the increase in anemia knowledge in female students p value = 0.012 < 0.05. Conclusions: This study concludes that there is an influence of WhatsApp group-based digital intervention on increasing anemia knowledge among female college students, so this group WhatsApp-based digital health interventions method can be applied as one of the promotional efforts in the delivery of health education about anemia among women of productive age. Keywords: anemia, digital intervention, WhatsApp, knowledge