Background and Objective: Noncommunicable Diseases (NCDs) are a main challenge for health systems. Monitoring and evaluating modifiable behavioral risk factors are essential for managing NCDs. Deploying a risk factor management tool is essential to successfully address the crisis of NCDs in the Republic of Moldova. The study Objective was to evaluate the acceptability of implementing an ongoing risk factor surveillance tool which should enable timely collection and processing of detailed behavioral data to inform health decision makers and strengthen NCDs strategies. Methods: We performed a cross-sectional landline telephone survey in the Republic of Moldova based on systematic random sampling of 800 adult respondents (aged 18-69 years) using the US Behavioral Risk Factors Surveillance System (BRFSS) Methodology. Four main calling-outcome measures were used to assess population acceptability: (1) interview completion rate; (2) cooperation rate; (3) refusal rate; and (4) resolution rate. Results: Final disposition categories were assigned after all calling attempts were exhausted: 248 (31.0%) fully completed interview; 5 (0.6%) partially completed interview; 13 (1.6%) eligible respondent refusal; 222 (27.8%) no answer; 180 (22.5%) answering device, unknown whether eligible; 96 (12.0%) telecommunication barrier; 2 (0.3%) physical impairment; and  34 (4.2%) non-eligible participants.  The calling-outcome rates based on final disposition codes were: (1) interview completion rate 95.1% (95% CI 91.8% to 97.1%); (2) interview cooperation rate 95.1% (95% CI 91.8% to 97.1%); (3) refusal rate 1.8% (95% CI 1.1% to 3.1%); and (4) resolution rate 37.5% (95% CI 34.2% to 40.9%). Conclusions: High interview completion and cooperation rates, along with low refusal rates, indicate that adult Moldovans are likely to accept a landline telephone survey for the purpose of assessing behavioral risk factors. However, the low resolution rate indicates that response rates could increase significantly if alternate communication methods(e.g., mobile phones) were used.