Introduction: The Americas region is currently considered the most unequal in the world; therefore, to overcome these inequalities, human resources in health play a central role, that is why, it is considered necessary to strengthen in the health science programs, the teaching and learning of Social Determinants in Health to promote their intervention and approach. Methodology: A review of the literature on the teaching and learning of Social Determinants in the Americas was carried out, by searching for official documents and articles in databases (Web of Science, Clinicalkey, PubMed, Science Direct and Lilacs). 68 documents were selected and organized in the teaching and learning of Social Determinants, their relationship with Interprofessional Education, and their importance and social responsibility. Results: The region of the Americas has made significant progress in several countries in terms of the inclusion of public policies that act on determinants and that help human health resources to be formed with a primary care approach; However, the health sciences faculties in the region must deepen their knowledge of research and pedagogical strategies that facilitate the teaching and learning of determinants; in turn, progress is observed in the inclusion of Interprofessional Education in the region. Conclusions: The comprehensive approach to determinants in the region plays a fundamental role in reducing social inequalities and improving the health of its inhabitants.