Background and Objective: Surgical site infections (SSIs) represent a real public health burden, given their individual and economic repercussions. Several risk factors are involved in its occurrence. Our study aimed to describe the trend in the prevalence of surgical site infections in subjects operated at the Sahloul University Hospital Centre between 2012 and 2021 and to identify the associated risk factors. Methods: A descriptive cross-sectional prevalence study was carried out on patients operated on at Sahloul University Hospital with a single visit on a given day per department. All patients, operated on in the 30 days preceding the visit and/or for whom a prosthesis had been fitted during the year preceding the visit were collected. Socio-demographic and clinical data were collected using a synoptic form prepared from the medical records of the patients under study. Results: A total of 1111 operated patients were identified. The mean age was 48.9 ±22.3 years with a male predominance and a sex ratio of 1.57. The median length of stay was 10 days [5 - 19]. In our sample, the number of SSIs was 70, giving an average prevalence rate of 6.3%. The prevalence of SSIs in this sample showed a linear significant upward trend. Analysis by site showed 49 superficial and 21 deep infections. The occurrence of a surgical site infection was significantly associated with the placement of a prosthesis (p<10-3), length of hospital stays of 7 days or more (p<10-3), and ASA score greater than or equal to two (p=0.023). Conclusions: In the light of these results, the high rate of SSIs underlines the importance of strengthening prevention and control measures by tailoring a program targeting the suggested risk factors.