Background: During the confinement experienced in different countries due to the COVID-19 pandemic, symptoms related to mental health were identified as a consequence of this stage, such as stress, so it is essential to identify the factors that positively or negatively influence the to start with early identification and attention programs. General Objective: Determine the association between social skills associated with stress in university students after returning to face-to-face classes. Methodology: A cross-sectional, prospective, observational and analytical study was carried out between January and April 2022 in Veracruz-Boca del Río, including university students of both sexes, in face-to-face classes, excluding subjects with a previous diagnosis of stress, anxiety or who do not they wanted to participate. The main variables studied were social skills (degree of assertiveness, communication, self-esteem and decision-making) and stress level. Surveys were conducted using Google Forms, including the social skills test (a.Cronbach 0.75) and the perceived stress scale (a.Cronbach 0.84). Statistical significance was assigned with a value of p<0.05. Results: 485 participants were included, 83.6% men and 16% women. Sex, age, major studied, and academic degree had values of p>0.05, while other factors (OR/CI95%) such as having an average of 6-7.9 (0.2/0.1-0.6) or 9-10 (1.8/ 1.1-2.9), as well as the degrees of low assertiveness (0.05/0.01-0.1), low average (0.3/0.2-0.9) or very high (2.8/1.3-6.1), low degree of communication (0.2/0.1-0.4 ) or high average (2.4/1.2-4.8), degree of low self-esteem (0.2/0.1-0.4) or high (3.2/1.5-6.9) and degree of low (0.3/0.1-0.5) and high (2.4/1.3) decisions -4.5) showed values of p<0.05 for the perception of stress. Conclusions: Being a worker is positively associated with the development of stress in students, while school achievement, the degree of assertiveness, communication, self-esteem and decision-making are both positively and negatively associated with the development of stress, according to to the intensity of each of these characteristics.