Background: Vasalgel is a new proposal in temporary contraceptive methods for men that shows clinical advantages in its use compared to female hormonal methods. Objective: To determine the factors associated with the intention to use Vasalgel. Methods: A cross-sectional, prospective study was carried out between August and December 2021, men residents of Veracruz aged between 20 and 34 years were included. The sexual machismo scale (Cronbach 0.91) and the Questionnaire on knowledge of responsible sexuality in young people (KR-20 = 0.57) were applied through Google Forms®. SPSS v22 software was used for data analysis, X2 test with Odds Ratio (OR) and 95% confidence interval (95%CI) and MannWhitney U test. assigning statistical significance with p<0.05. Results: 446 men were included, 52.2% with a high level of knowledge about responsible sexuality; 41.3% knew about the "Vasalgel" method, after explaining about this method, 74.9% showed a positive intention to use it. The factors associated with the intention to use Vasalgel (OR/95%CI) were having a bachelor's degree or higher (OR 5.9 / 95% CI 3.5-9.9), being an atheist (2.6 / 1.1-5.9), having a girlfriend (2.7 / 1.5-5.0), having had two or more sex education courses (3.6/2.0-6.3), not having children (10.0/5.7-17.3), using condoms without methods by the partner (3.0/1.8-5.1), knowledge of responsible sexuality high (5.0/2.8-9.0), medium (0.02/0.003-0.1) and low (0.1/0.01-1.9), living with your partner (0.2/0.01-0.4), and sex education courses only in high school (0.1/0.04) all with p<0.05. The participants with the intention of using vasalgel obtained lower points on the sexual machismo scale, likewise, the patients with more sexual education obtained lower scores on the sexual machismo scale (p<0.05). Conclusions: The level of knowledge about sexuality and machismo represent changes in the attitude of patients to favor the intention of using Vasalgel, as well as the sources where this knowledge is generated.