Background and Objectives: Educational games are technologies that seek to ensure the engagement and involvement of their players, in a teaching-learning process through the game in a differentiated and dynamic way. The objective of this study was to develop a serious game on the prevention of neonatal mortality, as an educational technology for Primary Health Care nurses. Methods: Methodological research, developed in two stages: 1 –search, selection and definition of game content; 2 - development of the serious game, in the stages: Concept, Pre-production or Planning, Prototype, Production, Alpha, Beta and Gold Phase. Results: the content of the game are real cases of neonatal death, classified as preventable, and which have already been investigated by the Municipal Committee for the Prevention of Maternal, Child and Fetal Mortality. For the selection of cases, an e-Delphi consensus panel was developed, with five members of the committee, who after analysis answered a Likert Scale: (0 - nothing relevant, I dont see the need to include; 1 - slightly relevant , but can be included; 2 - relevant, this could be it; 3 - very relevant, it would be very good to include; 4 - essential, must be included). The three cases selected to compose the content of the game were: newborn affected by maternal hypertensive disorders, newborn affected by maternal infection in the genital tract and newborn affected by isthmus-cervical incompetence. Thus, in the serious game, the player creates his Avatar (a nurse), who is faced with the cases, being instigated to choose the best conduct of care for the pregnant woman. Considerations: we believe that it is necessary to innovate in teaching strategies, through attractive and interactive processes, based on real situations that allow active learning, reverberating in a qualification of the Primary Health Care professional for adequate prenatal care.