The spread of the new coronavirus SARS-CoV-2, discovered in China in January 2020, led to a pandemic as early as March 2020. On March 13, 2021, the number of Morocco confirmed cases reached 488 632, and 8 718 deaths were recorded. The province of Khouribga recorded its first case on March 13, 2020. It was a Moroccan residing abroad (Italy). Until March 13, 2021, had 4239 confirmed cases, of whom 4086 were cured and 153 cases of death by COVID-19 including 115 cases at the hospital level. This study aimed to identify the risk factors associated with mortality of patients hospitalized with COVID-19, in Khouribga provincial hospital. This was a case-control study conducted from March 13, 2020 to March 13, 2021.The research involved 339 Patients residing in the province of Khouribga, 113 deceased COVID-19 patients and 226 discharged patients were included as the case group and control group, respectively. Sociodemographic, epidemiological, clinical, biological, radiological, therapeutic and comorbidity variables on admission were collected from medical records. The risk factors were determined by bivariate and multivariate analyzes. The Backward Stepwise Regression demonstrated that age of 62+ years (OR = 3,10 ; IC 95% : [1,34-7,17]), patients reported having two or more comorbidities (OR =5,94 ; IC 95% : [2,05-17,23), Diabetes (OR = 3,23 ; IC 95% : [1,16-8,98]), lymphopenia <1.2×103 /mm3 (OR = 2,45 ; IC 95% : [1,09-5,46]), Oxygen saturation <89%(OR = 8,86 ; IC 95% : [3,60-21,78]), and Time between onset of clinical signs and admission to hospital > 7 days (OR = 3,30 ; IC 95% : [1,44-7,53]) were independent risk factors of mortality of COVID-19 patients. The risk factors identified may help to determine patients at high risk of death at an early stage and guide the optimal treatment.