Background: Neonatal mortality is a core indicator of neonatal health defined as death during the first 28 days of life. About half (47%) of global under-five death is contributed by the death that occur within the first 28 days of life (neonatal death). Though neonatal mortality has reduced by 25% between 2005 and 2016, it has shown an increment between 2016 and 2019. The Ethiopian national average of neonatal death (33 per 1,000 live births) was also higher than sub-Saharan Africa average. Objective: To summarize the best available evidence describing the problem of the worsening neonatal mortality in Ethiopia and potential solutions for addressing the problem.  Methods: The preparation of this evidence brief for policy came to our attention for two reasons: 1) While the world has targeted to reduce neonatal mortality to at least 12 per 1,000 live births in 2030, neonatal mortality in Ethiopia is persistently high in the last decade, and 2) there is big gap observed between the current national plans and performances. Electronic databases of systematic reviews (SUPPORT Summaries, Health Systems Evidence, PDQ Evidence, Epistemonikos, the Cochrane Library were consulted. The final selection of reviews for inclusion was based on a consensus of the authors. Findings: The brief identified effective and promising interventions for reduction of neonatal mortality and presented as community based intervention and continuum of care. Community-based intervention packages: 1.Intervention packages consisting of mainly building community-support groups or women's groups probably decrease neonatal mortality by 16%, 2. Intervention packages consisting of mainly building community-support groups or women's groups probably decrease neonatal mortality by 40%, 3. Community mobilization and home-based neonatal treatment probably reduce neonatal mortality. Strengthening continuum of care: Interventions linking pre-pregnancy and pregnancy care probably reduce neonatal mortality by 21%.