Introduction:
In temperate countries of the southern hemisphere, influenza surveillance showed an increase in influenza circulation in 2022 season, anticipating a peak of influenza cases in the Northern hemisphere during 2022/2023 season. The Italian Health Ministry strongly recommend coadministration of seasonal influenza vaccines with other vaccines, including bivalent COVID-19 vaccines. The Vaccination HUB of University Hospital (UH) of Palermo, since the beginning of the campaign, administered over 90,000 doses of COVID-19 vaccines and more than 900 influenza vaccines have been co-administered with COVID-19 vaccines in the 2021/2022 season.

Materials and methods:
Data were collected from October to December 2022 at the Vaccination Hub of UH of Palermo, using a self-administered online questionnaire to subjects afferent to the Center, by Google® Forms platform. The research group had access and recorded all data on a password-protected Excel file (ver. 1997-2003). The questionnaire consisting in 15 items, the informative of the study and the consent form was approved by the Ethic Committee of the Palermo’s UH

Results:
Overall, 904 subjects answered the questionnaire. 74.5% of the respondents were willing to receive the co-administration with the Covid19 and seasonal influenza vaccines. The main reason reported for accepting the co-administration was confidence in the official recommendations (43.5%) whereas 46.6% were not willing to receive the co-administration for fear of side effects. At the multivariable analysis subject with age ≤59 years (AdJOR: 0.48;CI95%:0.31-0.75) and those who received the two vaccines co-administered during the last season (AdJOR: 87.1;CI95%:61.4-463.8) were significantly associated with coadministration during 2022/2023 season.

Conclusion:
First data obtained from this study show that those who received Covid19 and seasonal influenza vaccination in the same session also in the 2021/2022 season are willing to receive the co-administration of the two vaccinations again for the current season, arguing for the absolute safety and efficacy of the co-administration.