Background and Objective: The adherence to prevention actions remains a major public health issue. French Health Examination Centres (HEC) provide preventive health examinations. However, it is difficult to get people to attend these prevention consultations. The aim of this study is to test different strategies related to the promotion of preventive health examinations based on social marketing techniques, including the use of segmentation. Methods: Intervention research with a mixed approach was conducted using medical and administrative databases from the local health insurance system in 2019. The study’s population consist of 124.377 people +18 years, living in the Loire department and already targeted to a preventive examination. Multiple correspondence analyses were performed to summarize information from 31 variables related to sociodemographic and medical characteristics into a set of continuous principal components (PCs). The population was segmented into eight clusters based on a hierarchical cluster analysis applied to the 10 first PCs. 34 individual interviews were hereafter conducted to explore barriers and facilitating factors related to health examination invitations. Results: We focused on 3 clusters with social vulnerability criteria: cluster 3 (14%) had a higher frequency of young people without health insurance and with poor adherence to health examinations; cluster 4 (15%) was represented by low-income families with better adherence to the healthcare system; cluster 7 (10%) grouped people aged 40-70 years old not affiliated to the general healthcare system and with a lower frequency of health examinations. The qualitative study showed barriers such as ‘misunderstanding the content’, ‘not concerned’ by health examinations, and ‘intended to people who don’t care about health ‘. Conclusions: Social marketing campaigns have been implemented with carefully selected messages that communicate the most relevant information to the segments. The next step will be to assess whether the strategies improve adherence to the preventive health examinations.