Introduction: Traumatic brain injury can significantly change among partners in several functions of their life. Unexpected role changes can arise suddenly without preparation; this may be temporary or even permanent. This indicates significant impact on partner’s quality of life. Hence, current study aimed to measure the quality of life among partners of TBI survivors. Methodology: The study adopted descriptive research design; data was collected from 43 spouses at the time of admission and follow up after 3months. Semi- structured questionnaire was used to collect the patient and spouse’s demographic details. WHOQOL was administered to measure the quality of life at the time of discharge and during the follow up. Data was analysed by using R software. Results: 7(17.5%) male spouses and 33(82.5) female spouses had participated in the study. The Results Findings identified significant differences in physical health (pre 35.89±8.89 and post 43.39±7.16) ≤ 0.001. Environmental support was statistically significant differences ≤ 0.042 (pre-52.57±9.80 and post 56.09±7.03). However, there is no statistically significant differences were not observed in the domains of social support and psychological health domains. Conclusions: The study concludes timely surgical interventions and long-term psychosocial intervention can improve the quality of life of the partners of the TBI survivors. Keywords: TBI, partners, QOL