Background and Objective: Hypertension, coupled with prehypertension and other hazards such as high blood pressure, is responsible for 8·5 million death from stroke, ischeamic heart disease, other vascular diseases and renal diseses worldwide.Hypertension is the fifth commonest cause of outpatient morbidity in Ghana. Some evidence has illustrated geographical variation in hypertension and it seems to have a heavy toll on women in southern Ghana compared to the north. This study seeks to determine the prevalence and associated factors of hypertension among women in southern Ghana using the most recent demographic and health survey (DHS) data set.  Materials and Methods: This study used data of 5662 women from the current DHS data from Ghana that was conducted in 2014. Data were extracted from the women’s file of the 2014 Ghana DHS. The outcome variable of this current study was hypertension and it was measured by blood pressure, according to guidelines of the Joint National Committee Seven (JNC7). Multivariable binary logistic regression analyses were performed to establish the factors associated with hypertension at the individual and community levels. Results: Prevalence of hypertension among women in southern Ghana was 16%. Women aged 40–44 years (aOR=8.04, CI=4.88–13.25) and 45–49 years (aOR=13.20, CI=7.96–21.89] had the highest odds of hypertension relative to women aged 15–19 years. Women with two births (aOR=1.45, CI=1.01–2.07) and those with three births (aOR=1.47, CI=1.01–2.15) had a higher likelihood of being hypertensive. Greater Accra women had higher odds (aOR=1.35, CI=1.02–1.79) of being hypertensive relative to the reference category, women from the Western region. Conclusions: This study has revealed the prevalence of hypertension among women in southern Ghana. The associated factors include age, parity, region, and occupation.