Materials and methods:
The analysis were performed using two systems: “Farmanalysis”, which evaluate pharmaceutical expenditure and antibiotic therapy stream both territorial and hospital; “Health Card (TS)” which allows to investigate individual health spending data to the Internal Revenue Service. These data have been stratified by age group and gender.

Results:
Through historical comparison of antibiotic consumption, the highest consumption was observed in the 45 to 64 age group, followed by the over 75 age group. During the pandemic phase and the adoption of containment measures have resulted in a drastic decline in antibiotic prescriptions. A difference of -17.75% was observed in our province compared to the pre-pandemic period resulting in a -25% reduction in healthcare expenditure. At the same time, the shortage of first-class antibiotics led to an overprescription of old-use molecules such as Trimethoprim (+12.93%) and amphenicides (+27.27%).

Conclusions:
Our study demonstrates how the application of social distancing measures and proper use of protective equipment can affect the transmission of airborne diseases and how communication by professionals in the field can increase the informed use of antibiotic therapy by the population. Italy represents together with Greece the tail-end of Europe, so much so that 7-10% of patients encounter a multi-resistant bacterial infection. This issue, therefore, requires a multidisciplinary strategy that involves taking care of the individual from a One Health perspective.