Neighborhood physical disorder is an indicator of urban disinvestment that may act as a psychosocial stressor.  This study tested associations between observed neighborhood physical disorder and tobacco use, alcohol binging, and sugar-sweetened beverage consumption among a large population-based sample.  Individual-level data of this cross-sectional study were from adult respondents of the New Jersey Behavioral Risk Factor Surveillance System, 2011-2016 (n = 62,476).  Behavioral Risk Factor Surveillance System is the largest continuously conducted health survey system in the world.  Aggregated area-level observed neighborhood physical disorder were from virtual audits of 23,276 Google Street View streetscapes.  Tobacco use (current cigarette smoking or chewing tobacco, snuff, or snus use), monthly binge drinking occasions (5+/4+ drinks per occasion among males/females), and monthly sugar-sweetened beverages consumed were self-reported.  Logistic and negative binomial regression models were used to generate odds ratios, prevalence rate ratios (PRR), 95% confidence intervals (CI) by levels of physical disorder.  Compared to the lowest quartile, residence in the second (PRR: 1.16; 95% CI: 1.03, 1.13), third (PRR: 1.24; 95% CI: 1.10, 1.40), and fourth (highest) quartile of physical disorder (PRR: 1.24; 95% CI: 1.10, 1.40) was associated with higher monthly sugar-sweetened beverage consumption.  Associations involving tobacco use and alcohol binging were mixed.  Observed neighborhood disorder might be associated with unhealthy behaviors, especially sugar-sweetened beverage consumption.  Studies across globally diverse urban setting are needed to explore external validity and motivate urban policy recommendations.