Background and Objective: Pregnant women are more susceptible to more severe Sars-CoV-2 infections, therefore the Brazilian ministry of health recommends immunization since July 2021 to reduce maternal morbimortality. This study aims to describe the mortality profile of Brazilian pregnant women due to COVID-19, in the pre- and post-vaccination period. Methods: A descriptive, cross-sectional, and comparative study of notifications for severe acute respiratory syndrome to COVID-19 in pregnant women in Brazil, based on extracted data from the influenza epidemiological surveillance information system from epidemiological week 1 to 26 of 2021 and 2022. To perform the analyses, the statistical software SAS in 9.4 version was used, and a significance level of 5% was considered. Results: There were 883 deaths of pregnant women with Sars to COVID-19 in 2021 and 10 in 2022. In 2021, those who were 35 years or older, lived in the northern region, had fever, cough, dyspnea, respiratory distress, saturation lower than 95%, comorbidities, obesity, admission to the Intensive Care Unit (ICU), need for ventilatory support, were not vaccinated, and had an incomplete vaccination schedule were the ones with the highest proportion of cases that died. In 2022, pregnant women were 35 years old or older (50%), from the northeast region (40%), and brown (66.7%). Regarding clinical manifestations, fever (83.3%) and cough (62.5%) were the most identified symptoms. With regard to risk factors, 80% of pregnant women had at least one comorbidity and heart disease was the most prevalent (66.7%). Between these pregnant women, 66.7% needed ICU and 77.8% needed ventilatory support. As for vaccination, 70% were not vaccinated. Conclusions: The study allowed the characterization of the epidemiological profile of pregnant women with Sars to COVID-19 who died in Brazil. This profile may be related to the social determinants of health and the difficult access to health care services.