Background and Objective: Coronavirus disease (COVID19) has spread worldwide in a short time. It caused a lot of deaths of infected patients. Mortality data provides insight of fatal consequences among population. Risk factors for mortality have not been well summarized, but it was possible to show findings on the association between age, gender and comorbidities from COVID-19 infection. Mortality statistics are fundamental to public health decision making. Mortality varies by time and place and its measurement is affected by some biases that have been exacerbated during the pandemic. This paper aims to present mortality from the COVID-19 pandemic in Belgrade, Serbia. Methods: An analysis of death certificates shows an insight into the causes of death of Belgrade inhabitants. The paper presents data from database of deceased persons in Belgrade, 2012- 2021, analyzed using frequencies and incidence rates by gender, age groups, month of death. Results: Mortality (mt) incidence rate in Belgrade 2012 - 2021 is increasing. The highest mortality rate was in 2021, 17,72/1000 population at the age 20 to 64, the highest rate was also in 2021, male (м) 6,73/1000, female (f) 3,48/1000 older age (65 and more) shows highest mt rates in 2021, male 86,92/1000, female 63,46/1000 between march 2020 and December 2021, highest mortality rate from covid19 in man and women at the age 20-64 was in October 2021 (m: 39,12/100000, f: 20,32/100.000). Man 65 and older most frequently died in December 2020 (479,67/100.000), women in October 2021 (282,04/100.000). most common comorbidity were diseases of circulatory system, endocrine, metabolic diseases, neoplasms, etc. Conclusions: Older age (65 years old), male gender and particular comorbidities were associated with greater risk of death from COVID-19 infection in Belgrade, Serbia. These findings could help clinicians and public health authorities to prevent unnecessary death outcomes.