Background/Objectives:
In Mexico, mortality from motor vehicle traffic accidents (MVTA) is one of the main causes of death in the country; Coincidentally, the number of registered motorcycles has increased in recent years. While the increased risk of injuries faced by users of this type of vehicle has been documented, this study aims to analyze the evolution of mortality from motorcycle accidents (MA) by sex and age in Mexico in the last two decades and its association with the number of registered vehicles of this type.

Methods:
This study is based on official sources of information. MVTA and MA were classified according to the Tenth International Classification of Diseases. Age-standardized rates were calculated for each sex between 1998 and 2020. Through a regression analysis, both the rate behavior trend and the association between the rate and the number of motorcycles in Mexico were calculated. Likewise, the proportional weight of deaths from MA in the total number of deaths from MVTA was calculated.

Results:
The study reveals that the mortality rate from MA increased in Mexico by more than 800% in both sexes in the period analyzed. The highest rates are observed between the ages of 15 and 29 in men and between the ages of 15 and 19 in women. A strong correlation is observed between the registered number of motorcycles and mortality from MA. On the other hand, deaths from MA represented only 1% of deaths from MVTA in Mexico at the beginning of the period, but around 20% in 2020.

Conclusions:
Thus, it is necessary to implement specific actions to reduce this cause of death, especially in younger ages, given the growing number of motorcycles that circulate in the streets of Mexico and the few existing regulations.