Background: COVID-2019 outbreak started at Wuhan city in China, December 2019. On January, 2020 WHO declared it as, public health emergency and upon projection Sub-Saharan Africa was expected to see high number of deaths by 2020, because of poor and limited healthcare systems. In Tanzania by June 2020 there were 509 reported cases and 21 deaths from COVID-19 infection, among all reported cases were in cities. Since COVID-19 pandemic psychological impact was still unclear therefore understanding the psychological burden of the COVID-19 pandemic among caregivers is crucial in guiding policies and interventions to maintain their psychological well-being. Study Objective is to assess the psychological impact of COVID -19 on care givers of Dodoma Municipality in Tanzania. Methods: A cross-sectional study design were used, random sampling and purposeful sampling for select participants employed. The study established a brief, confidential, self-administered questionnaire containing DASS-21 (Depression, Anxiety, and Stress Scales) designed enquiry, in software data collector (KoBo toolbox), data analyzed by IBM SPSS software version 23. Results: The current study employed a sample of 246 Dodoma residents’ adults caregivers of COVID-19 patients, which found that psychological impact experienced by caregivers were commonly, anxiety, stress and depression was 83.7%, 76.4% 67.5 respectively, and peaking among nurses and family care givers, serving the frontline at hospital and quarantine center of COVID-19 patients. Mitigation of psychological burden, were achieved through taking precautionary measure of COVID-19, clear disease information, psychological support from family member, fellow staff and hospital managements, vaccination and least religious conviction. Conclusions: Generally, psychological burden has increased in COVID-19 caregivers, particularly among frontline health care workers, this may increase the risk of mood, sleep and functional disorders, therefore early psychotherapeutic interventions targeting this vulnerable group may be beneficial.