Background: Refugees in Europe have prevalence rates 3 times higher than the general population regarding depression, anxiety, and poor mental well-being (Priebe et al 2016). At the arrival in Europe, asylum seekers and refugees (ASRs), who are often victims of torture and intentional violence, have a higher incidence of PTSD. 5 years after the arrival, the prevalence of anxiety, depression and psychosis also increases (Bogic 2015). Italian Ministry of Health Guidelines support the early detection of at-risk individuals (2017). Objective: SAMIFO Center promotes early identification of at-risk ASRs, both in-house and in external services with the aim of treating and rehabilitating victims of violence, but also for secondary and tertiary prevention of post-traumatic and non-traumatic mental pathologies. Methods: SAMIFO carries out early detection and treatment of at-risk ASRs. The identification is carried out in different ways: through the operators working in first and second level ASRs centers, who indicate the reason for referral by e-mail; through in-house physicians (general practitioners and specialists) who identify at risk patients through a 12-item questionnaire administered by the clinician during the first visit; through the Territorial Commissions or through the Court in the event that symptoms occur during the hearings; through self-referral. Results: SAMIFO’s mental health unit makes around 1600 visits a year, including 300 first attendances. In 2021, 73% of first attendances were referred by external services, 26% by internal physicians, 1% was a self-referral. The 33% of first consultations and 40% of total referrals were affected by PTSD. 80% of patients continued the treatment, 19% received counseling and 1% were referred to external services. Conclusions: SAMIFO has developed a methodology for early identification and referral of at-risk individuals that extends beyond the service itself, promoting guidelines-compliance and best practices in ASRs services as well.