Background: In fact, of COVID-19 confirmed cases, Mongolia is in the top five countries in the West Pacific. A lack of practice to prevention from coronavirus infection period presents a need to improve the prevention, response, and risk communications of Mongolians and ensure the adaptability of citizens. Conducting the knowledge, attitudes, and practices towards coronavirus infection will help identify and address the population’s information needs and concerns, provide relevant information, and to save lives. Methods: The study was conducted participants from 3 remote provinces and 2 districts of Ulaanbaatar Capital city. Kazakh ethnic group in Bayan-Ulgii province, which make 3.9 precent of the total population, was selected through targeted sampling Methodology to determine whether cultural and religious factors influence attitudes towards spreading COVID-19. The survey data was collecting using quantitative, and qualitative methods among three specific groups (health specialists, general population, teenagers). Observations were performed on the population’s handwashing situation, duration, use of soap, wearing and removing masks, frequency, and social distancing behavior of people. Results: Positive changes made in the behavior of handwashing frequency (50.5% to 83.2%), wash hand in the correct order (21.4% to 39.1%), use soap regular (26.0% to 53.2%), wash hand duration (16.1% to 33.5%), the frequency of cleaning and disinfecting of home and the use of disinfections has been increased, the practice of wearing masks in crowded places and outdoors were increased by 6.8 percent. Conclusions: To divide the target group into children, adolescents, adults and the elderly and implement activities aimed for them. Promote and develop training program and curriculum for all level education institution and create a supportive environment. Continue to provide essential knowledge sharing activities.