The study is aimed to access the relation of Core-Self Evaluation and Academic Burnout among university students. Four Hundred and Sixty students (N=460) with age 18-32 including both undergraduate and postgraduate and male and female students. They were assessed using the Core-Self Evaluation Scale (CSES) (Judge et al.2003), the Copenhagen Inventory (CBI) proposed by Kristensen et al. (2005) and the Satisfaction with Life Scale (SWLS) (Diener E,1984). Convenient sampling technique was used to examine the relation between core-self evaluation and academic burnout, mediating role of life satisfaction and the existence of difference of experiencing life satisfaction by males and females. Results indicate that significant and negative relation between sore-self-evaluation and academic burnout. A partial mediating role of life satisfaction is also observed. Also, a significant difference in experiencing life satisfaction among the two gender is also seen by the results.