Background: Oral Health-Related Quality of Life (OHRQoL) Results from the relationship between and among oral health problems, contextual and social factors, and the body as a whole. Several studies have been conducted to investigate the effect of oral conditions on OHRQoL in the Indian population, with inconclusive Findings. Objective: This review will assess the impact of oral diseases on OHRQoL compared to individuals without oral disease among Indians.  Methods: PubMed and Scopus, CINAHL, Web of Science, and PsycInfo were systematically searched for english language studies conducted among Indians up to July 2022. Two independent reviewers performed the study search and screening through covidence software. The data extraction and quality assessment was facilitated using JBI SUMARI. PROSPERO registration Number: CRD42021277874. Results: Fourty one publications were included in this review (N= 23,090). Studies include both cross-sectional studies and randomized controlled trials. Based on the JBI critical appraisal tools, the quality of the included studies was low to high. Most of the studies fail to address the confounding issues. Thirty-seven studies were considered for the meta-analysis. Dental caries have nearly four times the chances of having a poor OHRQoL compared to those without dental caries [OR: 3.54 (95% CI 2.24- 5.60), ten studies, 4945 participants]. Periodontal disease assessed by Loss of attachment affects OHRQoL [ OR: 1.63 (95% CI 0.49, 5.51), three studies, 1364 participants]. Edentulism has 2.49 odds of having a poor OHRQoL compared to those without functional Edentulism [ OR: 2.49 (95% CI 1.27, 4.90), two studies, 368 participants]. Conclusions: Despite the various definitions of the exposures and instruments used to assess OHRQoL, our review found that people with dental caries, periodontal disease, functional edentulism, and prosthetic needs have a significantly higher experience of poor quality of life.