Background: Appropriate antibiotic prescription is crucial to antimicrobial stewardship, supporting antimicrobial resistance reduction. In Irccs Policlinico San Donato, Milan (Italy), at the start of 2022 a motivated request form for the prescription of several antibiotic and antifungal medications was introduced. Furthermore, Electronic Health Record (EHR) for the management of pharmacotherapies was implemented in several departments of polyclinic in July 2022, allowing a direct monitoring of prescriptions by the pharmacists, which was not possible before. The aim of this study is therefore to evidence the importance of EHR for the direct monitoring of requests, evaluating also the economic loss resulting from the inappropriate prescriptions. Methods: Overall, 55 motivated requests for meropenem, daptomycin and caspofungin sent during September and October to the pharmacists were reviewed. We compared the delivered doses with the relative administrations through the EHR for each patient. We also estimated the economic loss resulting from the doses delivered but not administered. Results: There were 17 motivated requests for meropenem, 7 of which involved 70000 milligrams (mg) of delivered doses but not administered; 157000mg were administered without a corresponding motivated request. Regarding daptomycin, out of 30 requests, 13 involved 26660mg of delivered doses in excess while 37400mg were administered without a request. Out of 8 caspofungin requests, 4 involved 900mg of delivered doses in excess and 2090mg were administered without a request. Overall, €2016 were lost due to the excess delivered doses. Conclusions: The introduction of the EHR allowed a direct monitoring of motivated requests appropriateness; this is the first step to manage the inappropriate pharmacological prescriptions. Next step should be to integrate the motivated request form in the software, during the prescription of the medications that require it. This would prevent doctors from submitting wrong or incomplete requests, therefore strengthening antimicrobial stewardship and improving the appropriateness of their usage.