Introduction: Tobacco is a major public health threaten and several policies and laws were enacted to reduce the burden of tobacco-related diseases and deaths. We aimed to assess the impact of national smoking bans on per-capita cigarette consumption and mortality of acute myocardial infarction (AMI) in the European Union (EU) and in the United Kingdom (UK) and to assess which factors influence their effectiveness. Methods: We carried out an interrupted time series analysis including data of 27 Member States of the EU and the UK on per-capita cigarette consumption and AMI mortality. A multivariate meta-regression was carried out to investigate whether some factors influenced the effectiveness of smoking bans in terms of level and slope changes following interventions. Results: Around half of the interventions analyzed led to a level or slope change, or both, of per-capita cigarette consumption (17 out of 35) and AMI mortality (18 out of 36). As for cigarette consumption, the strongest level reduction was observed for the smoking ban issued in 2010 in Poland (rate ratio, RR: 0.47; 95% confidence interval, CI: 0.41, 0.53). Instead, the highest level reduction of AMI mortality was observed for the intervention introduced in 2012 in Bulgaria (RR: 0.38; 95% CI: 0.34, 0.42). Bans issued more recently or by countries with a lower human development index were found to be more effective at reducing per-capita cigarette consumption. In addition, smoking bans applying in bars were found to be associated with a higher effectiveness related to both cigarette consumption and AMI mortality. Conclusions: The results of our study suggest that smoking bans are effective at reducing per-capita cigarette consumption and AMI mortality. It is of extreme importance to monitor and register data on tobacco, its prevalence and consumption in order to be able to tackle with concerted efforts its health effect.