Background and Objectives: Female genital mutilation (FGM) continues to exist in Senegal despite the legal prohibition introduced by the government in 1999. Because of its consequences, it remains a public health problem. The aim of this study is to describe and identify the factors associated with FGM in Senegal. Methods: The analyses in this study had been done on the DHS 2019 data of Senegal. The DHS data included 7498 women aged 15 to 49 years. A multivariate analysis was performed to control for confounding factors. The dependent variable was the existence of female genital mutilation in women. Data were analyzed with STATA 17 software. Results: Women with FGM represented 29.09% (2181) of women. FGMs were performed in 14.24% of cases before the age of 5 years. Women who thought that FGM was justified by religion represented 13.78% (1033). However, 80.59% of women thought it was a practice that should stop. In most cases, 96.94% of the mutilations were performed by traditional excisers. The protective factors for the occurrence of female genital mutilation were the womans high level of education (secondary ajOR=0.63 [0.63-0.94]), level of wealth (ajOR: 0.62 [0.47-0.82]), belonging to the central region of Senegal, and Christian religion (ajOR:0.029 [0,02-0.83]). Risk factors for female genital mutilation in Senegal were female age 45-49 years (ajOR: 1.29 [1.06-1.56]), rural residence (ajOR: 1.29 [1.06-1.56]), ethnicity, and belonging to certain regions in the northeast and southeast of Senegal. Conclusions: To combat FGM, interventions should be targeted to certain regions and ethnic groups. Multi-sectoral interventions addressing the raising of womens empowerment.