Smoking is an addictive behavior; nicotine is the main substance responsible for physical and moral dependence. The aim of this study was to determine characteristics of Nicotine-physical-dependence among Tunisian smokers. We conducted a descriptive study, over 5 years (2015-2020), including all patients consulting voluntarily the smoking cessation unit in Sahloul University Hospital-Tunisia. The physical dependence on nicotine was measured via the Fagerström test for Nicotine Dependence (Six questions form, summing from Zero to 10). Smokers with a score of 7 to 10 were considered highly dependent on nicotine; score from five to 6 were considered moderately dependent and from 0 to 4 were not considered dependent. From 2015 to 2020, 450 smokers consulted our unit. When interviewing the patients, their moral dependence (addiction) to tobacco explained by themselves to gestural automatism (81.8%), stressful situations (76.7%) and the need for moral support (70.2%). As for the physical tobacco dependence, the Fagerström scale revealed that 46.2% (n=196) were highly dependent, 34% were moderately dependent and 20% were not very dependent. These highly addicted smokers were most often men (91.3%) had a higher average age than the lower dependency categories and were more often unemployed. The mean nicotine dependence score was 6.16±2.29. It was not associated with gender. It was, however, significantly associated with low level of education (p=0.001) and advanced age with a weak positive correlation (r=0.182, p<10-3). This level of nicotine dependence was, also, significantly associated with a high average number of cigarettes consumed daily (p<10-3), a high level of CO exhaled at each visit (p<10-3) and a high Hospital Anxiety and Depression scale (p<10-3). Smoking cessation requires comprehensive management. Our cost-free unit attracts mostly highly dependent smokers, but also patients with varying level of dependence. Successful quitting depends on factors related to the individual, his environment and the care-quality.