Background: In Mexico, the commercialization of vapers is considered illegal due to the damage it produces in its users, however, the use of electronic cigarettes has spread among young people worldwide, recognizing as users a total of 1.1% of the national population. Objective: To determine the factors associated with vape consumption in young people during the covid-19 pandemic. Methods: A cross-sectional, prospective study was carried out between December 2021 and April 2022, men and women residents of Veracruz aged between 12 and 25 years were included, excluding participants with a clinical diagnosis of anxiety, with treatment for addictions or anxiety, evaluating the reasons why which vape consumption is made, as well as the changes in consumption since the start of the pandemic. SPSS v22 software was used for data analysis, Chi2 test with Odds Ratio (OR) and 95% confidence interval (95%CI) and MannWhitney U test. Results: 617 participants were included, identifying 15.5% of current vape users, 0.8% of the population stopped consuming during the pandemic, while 5.5% of the population started using it, 4.7% increased it, 1.1% decreased it, and 6.1% maintained their frequency of consumption. Age, sex, and perceived anxiety had values of p>0.05, while having less than secondary education (OR/95%CI) (3.1/0.14-0.69), being a student (0.3/0.12-0.8), having high socioeconomic level (1.59-1.0-2.5), having a job (2.19/1.3-3.6), perceiving that vape increases work performance (7.4/3.2-16.2), that it increases academic performance (6.7/3.12-14.4) or perceive anxiety reduction when consuming it (4.22/2.61-6.82) had a value of v<0.05. Likewise, those who vape their siblings (7.17/4.19-12.25), partner (9.14/5.14-16.2), relatives (2.24/1.44-3.49) or close friends (23.56/7.36-75.3) showed values of p <0.05. Conclusions: During the pandemic, the use of Vape in young people increased, having as associated factors being of a high socioeconomic level, low educational levels, being a worker and having close contacts who are consumers.