Background and Objective: It is known that climatic changes and the urban mobility are increasing the numbers of dengue cases. In 2019, were registered 5,2 million new cases, and World Health Organization aim to reduce mortality caused by this disease until 2030. Dengue is the main arbovirosis disease, being a viral infection transmitted to human through by infected mosquitoes, mainly Aedes Aegypti. In the last 12 years, were notificaded 16,942538 cases in Brazil, whereupon São Paulo is the most prevalent state (26.9%). The objective of the study was to establish epidemiologic profile of dengue in the State of São Paulo/Brazil, in the last 12 years. methods This is an observational, descriptive, cross-sectional, and retrospective study, which was carried out through the analysis of secondary data collected from the National System of Notification Appeals (SINAN) and from SUS Computer Department (DATASUS). Results: The total number of reported cases was 4,558,369 and 2015 was the year with the highest cases (1,033070). The cases were predominant in the female sex (53.7%), white people (54.4%%), high school completed (16.1%) and clinical and epidemiological criteria of confirmation (63.8%). Concerning hospitalization rates, there was a limited necessity of admissions (2.2%), as well as few deaths due to the notified disease (1557). Conclusions: There was a significant growth in the number of dengue cases in Brazil from 2019, during pandemic COVID-19, which represents a public health problem. Health promotion and prevention actions should be intensified in primary health care.