The aim of the present study was to analyze the epidemiological profile and spatial distribution of gestational and congenital syphilis cases. This is a descriptive, exploratory and retrospective research, with a quantitative approach, conducted in Indaiatuba - SP (Brazil). Data from case reports confirmed by gestational and congenital syphilis of the Notification Recording Information System from 2012 to December 2021 were used. With the Global Positioning System technology, case coordinates were collected, and with the Quantum GIS program, version 1.7.0, the maps were built. There were 386 cases of gestational syphilis, presenting a growth of 73% in the period. The highest prevalence occurred in young, brown women with low schooling and housewives. Higher frequency of diagnosis in the third gestational trimester was evidenced, with higher prevalence of primary syphilis. There were 172 cases of congenital syphilis, with a 85% growth in detection rate and age prevalence between 1 and 28 days of life. It reveals the fragility in the research management, making it detrimental to permanent education, to qualify the professionals, in order to institute early identification, timely treatment and effective follow-up, to evaluate the quality of prenatal care in the municipality. Through the technique of simple regression artificial intelligence, the perspective for the coming years was analyzed in case the municipal management does not study ways to circumvent this public health problem.