Sonali chicken production increased substantially during the last two decades in Bangladesh. However, different prevalent diseases hampered its normal growth. Irrational and inappropriate use of antimicrobials is commonly occurred which contribute to the development of antimicrobial resistance (AMR). The current study was therefore attempted to assess the burden of diseases along with antimicrobial prescription patterns. A total of 1690 drug prescriptions for infectious diseases in Sonali chickens in Bogura during 2020-2021 was extracted from the e-prescription database of 3769 poultry cases for assessing the disease status and antimicrobial prescription patterns. Data extracts were entered into MS excel and cleaned and sorted before exporting to STATA/SE-13 for epidemiological analysis. The proportion of cases was dominated by mixed diseases of viral, bacterial and other infectious cases (28 %, n=474), followed by viral diseases (17.5 %, 296), bacterial diseases (4.5 %, 76), protozoan disease (4.0 %, 67). Antibiotics were widely prescribed regardless of case type (84.4- 97% cases). The highest proportion of antimicrobials was used in protozoan cases (97 %, 65), followed by viral alone (92%, 273), mixed (91.7%, 435) and bacterial alone (90.8%, 69). Single antibiotics (61.3%, 980) were prescribed widely followed by combined (14%, 224) and double (2.4%, 39). Tylvalosin (42%, 669) was more commonly prescribed for almost all disease types. Different fluoroquinolones and florfenicol were predominantly prescribed for undiagnosed (11.8%, 70) and bacterial cases (16%, 11), respectively. Colistin combined (3.4%, 55) was prescribed highly followed by aminoglycosides (2.4%, 38). Moreover, antiviral drugs were prescribed for 33.5% viral, 33% bacterial, and 30% protozoan cases. Immuno-stimulant was prescribed for 18% viral and bacterial cases. Considering the results, it is practical to include this e-prescription system to existing web-based surveillance system to know the disease rank and antimicrobial use pattern timely, thus support to preventive program and antimicrobial stewardship approach.