Background and Objectives: There is a tremendous need for a global health workforce that is competent to deal with emerging global health issues. Global health education and training provide unique collaborative opportunities to address the global burden of disease by training the next generation of global health experts. The Mel and Enid Zuckerman College of Public Health (MEZCOPH) at the University of Arizona is an example of an institution that has recently invested in global health infrastructure and academic programs. MEZCOPH established the Global Health Institute (GHI) to provide innovative and transformative public health education, scholarship, research, advocacy, and leadership training for health care professionals worldwide. Methods: The rapidly evolving convergence of the physical, digital and biological fields is reshaping and transforming higher education. This Fourth Industrial Revolution will lead to the continuous Introduction of new technologies which will mandate new and innovative ways of experiential learning. The new and emerging digital media technologies provide feasible and cost-effective alternatives to traditional classroom instruction. Results: The GHI implemented an innovative approach to internationalization by establishing a worldwide network of global partners and/or micro-campuses to deliver collaborative educational and training programs including unique dual degree programs overseas to local students and different summer and global engagement programs. These programs rely on the full collaboration between GHI and its worldwide partners. I will discuss our micro-campus experience and other GHI ongoing programs with our network of global partners. I will highlight the successes, challenges, and lessons learned Conclusions: Collaborations in global health education and training, while tremendously advantageous, can be demanding and challenging.