Background and Objective: UAE observes overweight/obesity, physical inactivity, high stress levels, smokers and unhealthy dietary practices are major determinants that influence the prevalence of heart diseases and comorbidities. Hence, this research assessed the determinants of cardiovascular diseases (CVDs) among Indian expatriates residing in Ajman, UAE. Materials and Methods: This cross-sectional study was conducted among 279 Indian expatriates using self-administered questionnaire. The participants were recruited after obtaining consent from them. The SPSS version 27 was used for analysis. Chi square test was used to assess the association between dependent and independent variables. Results: Among the respondents 54 (19.4%) had CVDs. Males reported having CVDs at a rate of 30 (24.6%) over the age of 40, compared to females at a rate of 24 (15.3%) over the same age. This correlation demonstrates that men are more prone to CVDs than women. This includes South Indians, 44 (33.1%): Other States, 10(6.8%); married people, 45 (35.2%): single people 9 (6%); family history of CVD (first-degree relatives); insufficient sleep: frequency of sleep: those who do not adhere to a regular sleep pattern; and those who don’t exercise showed a statistically significant correlation. Conclusions: The determinants such as age, gender, topography, family history of CVDs, regular sleep pattern, stress, energy drinks, red meat, alcoholism and physical exercise dispose adult Indians residing in Ajman, UAE to various CVDs. Age above 40 years, male gender, hailing from South Indian states, married, family history (first degree relatives), inadequate sleep, frequency of sleep, who don’t follow a regular sleep pattern, and those who don’t exercise showed a statistically significant association.