Background and Objective: COVID-19 vaccines represented a light in the darkness, but a great disparity in vaccination coverage between countries still persists after 18 months their Introduction. As this global public health issue rises, questioning the reasons becomes mandatory: the aim of this work is to analyse several variables to identify possible determinants of COVID-19 vaccination. Methods: A retrospective observational study was conducted using pooled secondary data sourced from institutional sites, including 205 countries and territories worldwide. Two indicators of vaccine coverage were identified as outcomes: The percentage of the population vaccinated with at least one dose and the total doses administered per 100 residents. A raw and an adjusted for delivered vaccine doses multivariate GLM were fulfilled using R. Variables were in multiple fields: socio-demographic, cultural, infrastructural, economic, political and of health system performance. Results: GDP per capita (Odds = 1.401 (1.299 to 1.511) C.I. 95%), Access to electricity (Odds = 1.625 (1.559 to 1.694) C.I. 95%), Political stability and absence of violence/terrorism (Odds = 1.334 (1.284 to 1.387) C.I. 95%) and Civil liberties (Odds = 0.888 (0.863 to 0.914) C.I. 95%) proved to be strong determinants of COVID-19 vaccination. Other several variables displayed a statistically significant association with outcomes, although the associations were stronger for Total doses administered per 100 residents. There was substantial overlap between raw outcomes and their adjusted counterpart. Conclusions: This pioneering study identified strong determinants of vaccination coverage such as GDP per capita and Access to electricity. Political decision-makers should consider these Findings in order to organize a mass vaccination campaign able to reduce inequalities between nations in a pandemic context.