Background and Objective: The effect of patient education on pain has been shown to be comparable to that of certain analgesics. LE DECLIC EPRI intervention, developed according to the Behavior change wheel theory of S. Michie, aims to respond to avenues for improvement in order to increase the effectiveness and scope of these interventions with the painful population followed in cancer centers. Methods: This is a randomized stepped wedge trial carried out in the five participating hospitals for three and a half years. Two randomized groups are compared for all outcomes: an experimental group with centers providing the LE DECLIC EPRI intervention versus a control group providing usual care. The transition from the control group to the experimental group will take place every 6 months, in order to implement the intervention gradually in the centers. 270 patients are expected, 54 per center. The achievement of the multiple objectives of this study is assessed with the corresponding analytical methods, and a mixed qualitative-quantitative method will be used. Results: The expected results will relate to the understanding in vivo and over time of the necessary transformations, in particular through the analysis of the follow-up notebooks collating the events and experiences, filled out by each team: training in patient éducation, local influencer module, general practitioner module and the teams of educators in each center. Conclusions: Concomitantly constructing interventional research makes it possible to implement care while analyzing it. The corrective measures that leave room for all the creativity of the care teams combined with the patient experience are thus captured. A toolbox and recommendations for the optimal transfer and implementation of the intervention can be produced.