Background and Objectives: Disability constitutes a major social problem. Globally, 1 billion people - approximately 15% of the population- live with some form of disability, of which one-third is as a result of preventable injury. Furthermore, nearly 4% of this population experience significant difficulties in functioning often requiring health care services. In recognizing the urgent need to attenuate the social and health inequalities associated with disability, 74th the World Health Assembly in 2021 adopted a resolution to provide the highest attainable standard of health for persons with disabilities by making the health sector more disability- inclusive and therefore ensuring no one is left behind in achieving the Sustainable Development Goals. The social determinant-based approach to disability related to catastrophic injury has seldom been applied in this area. We aim to describe the impact of health determinant approach on injury related disability rehabilitation outcomes not otherwise documented. Methods: Prospective, mixed methods study within a Participatory Action Research approach with three-phase design: Phase 1: Scoping review of existing literature on catastrophic injury and disability. Secondary data review about injury and disability. Phase 2: Participants with catastrophic injury and disability: Development and implementation of a comprehensive general assessment database (demographics, injury details, social determinants measures, quality of life, knowledge and skills on disability), Open-ended survey; Clinical assessments. Data analysis. Phase 3: Key experts working with participants and/or with specialised knowledge: Qualitative interviews. Results: The results will showcase the impact of applying a health determinants approach that has the potential to inform improved community-based rehabilitation and health service delivery of injury related disability. Conclusions: New evidence will be generated regarding effective health determinants approach for addressing injury related disability and reducing health inequalities. Such information will be important to instigate the needed paradigm shift from conventional approach to disability to a social- determinant one.