Introduction: Following the confirmation of two (2) cases in the health district of Bougouni on 03/12/2019. We conducted an investigation whose objective was to describe the cases of yellow fever in the Manankoro health area in time, place and people and to put in place control and prevention measures against the epidemic. Methodology: We conducted a cross-sectional descriptive study in December 2019, a case of yellow fever was any person who stayed in Manankoro or surrounding village between October 20 to December 05, 2019 and who presented during this period the following signs: Fever or notion of fever in the previous days and jaundice in the 2 weeks following the onset of the signs. We conducted a search for other unreported cases based on data collected using a questionnaire. The data was analyzed in time, place and person. Results: Case confirmed by the laboratory, this is a 25-year-old adult, farmer, male gender, residence Kémingouara / Republic of Côte dIvoire, came on November 06, 2019 for consultation at the Lafia cabinet in Manankoro in a table of coma and referred to the CSRéf of Bougouni for better care where he died 11 hours after his blood sample on 08/11/2019. Conclusions: The investigation made it possible to identify 12 additional cases among which 3 cases of death, the age group of 30 to 34 years was the most represented, that is to say 33%. The male sex was predominant with 10 cases. Fever, jaundice and vomiting were the most frequent symptoms. The Aedes species responsible for yellow fever was not found during this investigation.