Objective: To elucidate cardiovascular risks in the homeless population of São Paulo, stratifying through nursing diagnoses. methods This is a field research of a quantitative and transversal character, whose study target is the homeless population in the central regions of São Paulo. A questionnaire containing questions related to cardiovascular health was applied, Blood Pressure (BP) and anthropometric measurements were measured in volunteers aged between 18 and 60 years, between November 2019 and March 2020. the development of CVDs and then the results obtained will be presented. Results: This population has several RF for cardiovascular diseases such as; the substitution of water for alcohol, insufficient knowledge to the RF, lack of access to health services, indicating the need for education and health prevention. When asked about drinking water consumption, 34% said they consumed more alcohol than water, in which the BP levels were 142 per 94 mmHg and the pulse was 91 beats per minute (bpm). This indicates the influence of exchanging water for alcoholic beverages on the elevation of blood pressure values. Conclusions: Nursing diagnoses: Risk of Unstable Blood Pressure, Risk-prone health behavior characterized by substance abuse. This study was carried out in the pre-pandemic, today São Paulo has more than 31000 PSR. It is evident that this is a matter of public policies and human rights that ensure that all citizens have the right to basic needs.