Background and Objective: Individual preventive behaviours are one of the key ways needed to prevent the spread of COVID-19. The objective of this study was to identify the factors associated with the adoption of COVID-19 preventive behaviors, focusing on use and trust of information sources about covid-19. Methods: A nationally representative cross-sectional survey of 30053 Japanese adults was conducted in February 2021. We estimated the associations between the adoption of COVID-19 preventive measures and a broad array of individual factors. A total of three multivariable logistic regression models was constructed to identify the factors associated with the adoption of each of three preventive measures: 3cs avoidance (“closed spaces”, “crowded places”, and “close-contact settings”), hand hygiene and respiratory hygiene. Results: The prevalence of preventive behaviours was 35.92% for 3cs avoidance, 80.43% for hand hygiene and 67.66% for respiratory hygiene. After adjusting for covariates, socioeconomic variables, psychological variables, and the use and trust of information sources were statistically significantly associated with the adoption of three preventive measures. Trust in social media was associated with lower odds (0.91, confidence intervals 0.86-0.96), while trust in healthcare professionals was associated with higher odds (1.10, 1.05-1.16). The number of information sources used and the odds of adopting 3cs avoidance were positively associated, e.g. An odds ratio of 2.70 (2.48-2.94) for five or more sources in reference to one source. In addition, the greater the number of social media used as an information source, the higher the odds of avoiding the 3cs, e.g., an odds ratio of 4.55 (2.03-10.19) for six or more sources in reference to none. Similar trends were observed for hand hygiene and respiratory hygiene. Conclusions: The findings indicate that access to multiple sources of information and social networks to provide public health messages may be important in promoting prevention measures for COVID-19.