Background and Objectives: The transformation of remote healthcare pathways (telemedicine) in Apulia starts a long time ago with the POR Puglia 2014-2020 projects: HLCM and TALIsMAn (winner of the Digital Innovation Award in Healthcare 2021) from which CORēHealth directly derives, set up at AReSS. Methods CORēHealth offers: HL7-FHIR interoperable web-cloud platform; Televisit, teleconsultation, telemonitoring, telecooperation and teleconference; Device tracking system; patient synoptic; central alarms; Mobile App for Citizens (Android and IoS); Integration with the Regional Health Information System, the Electronic Health Record and others.Results:The APP promotes the patients involvement in the care process: keeping in touch with your specialist doctor and caregiver (video calls and chat); consult the agenda of the televised programs with your care team; view your care plan; enter the vital parameters that are communicated to the doctor in real time; manage their clinical diary and possibly share it with the care team; facilitate the measurement of compliance with the treatment path (drug intake, lifestyle). From January 2022 the transformation of the Apulian Oncological Network into a digital key was started and therefore the training of the operators of the Oncological Guidance Centers and the Breast Units and the enrollment of about 23,000 cancer patients. Conclusions: AReSS has launched a virtuous path of training, change management and digital literacy for all users of the system (medical and administrative teams) and for patients to promote continuous training and the consolidation of digital skills. CORēHealth overturns the traditional patient care pathways, bringing, for the first time, digital innovation directly into their hands (App Mobile) allowing them to have their own medical history, their treatment plan and to maintain a constant and regulated dialogue with your doctor, the medical team and the care giver, as well as being able to take the most suitable measurements for the management of your pathology.