Background and Objectives: Patients affected by inflammatory bowel diseases (IBD) often require immunosuppressive treatments which may increase the risk of opportunistic infections. Several guidelines suggest to investigate patients’ vaccination status before starting any treatment and perform vaccinations against vaccine preventable diseases (VPDs). Nevertheless, vaccination rates in IBD patients are not suboptimal and may also be lower than those in general population. Aim of the study was to investigate vaccination coverage against VPDs and its possible determinants among a cohort of IBD patients. Methods: An anonymous validated questionnaire was sent by the Italian IBD patients’ association “AMICI-ETS” to their members through mailing lists and social media. Patients were asked to report their vaccination status and their attitude towards vaccinations between favorable, opposing, or uncaring. The factors influencing attitude towards vaccinations were examined calculating crude and adjusted odds-ratios (AdjORs) with 95% confidence-intervals (CIs). Results: The questionnaire was sent to 4039 patients with a response rate of 25.3% (n=1252).Socio-demographic and clinical characteristics. Overall, 79% have referred to be vaccinated against most of VPDs while 252 (20.7%) did not remember any previous vaccination. 1152 of respondents (88.8%) stated a positive attitude towards vaccines, while the rest were uncaring or against vaccinations (7.3% and 3.9% respectively). The determinant influencing the positive attitude towards vaccinations was the belief of possible return of VPDs with decline of vaccination coverage rates (AdjOR 5.67, 95% CI 3.45-9.30, p-value <0.001). Conclusions: Despite the high percentage of patients showing a positive attitude towards vaccinations which was mainly influenced by the greater awareness of VPDs with the decline of vaccination rates, study confirmed a low vaccination rate among IBD population. This may suggest a central role of physicians in prescribing vaccinations since most patients have a positive attitude, even developing vaccination campaigns to increase vaccinations’ rates in IBD patients.