Introduction: The COVID19 pandemic has caused global stagnation. All individuals, more so for people living with chronic health conditions such as HIV/AIDS are at high risk of contracting or developing problems. Health-related quality of life (HRQoL) is becoming an important outcome measure among PLHIVs. We assessed the health related quality of life, antiretroviral therapy adherence and its association with the sociodemographic and clinical characteristics among people living with HIV/AIDS currently enrolled at a tertiary government hospital treatment hub in Cebu City, Philippines during the COVID19 Pandemic. Methods: Descriptive cross-sectional study design was conducted from May to June of 2022. Simple random sampling was done to derive the sample population. Respondents were asked to answer a structured questionnaire. Health-related quality of life was assessed using WHOQOL-BREF  and medication adherence using SMAQ. CD-4 count and clinical staging was extracted from treatment hub registry. Results: A total of 385 respondents were included in this study.  Majority were 18-35 years old (66.5%), male (74.5%), single (78.9%), college graduate (70%), employed (64.4%), were living with their family (69.6%), at immunologic stage 1 (48.1%) and are clinically at stage 1 (57.4%) of the disease. Overall HRQoL amongst respondents was 61.65± 19.39. Furthermore, highest and lowest mean scores were related to environmental domain (64.13±22.48) and social domain (60.67±25.06), respectively. 69.35% of the respondents were adherent to ART.   Conclusions: The study showed that people living with HIV/AIDS currently enrolled at a tertiary hospital treatment hub during the COVID19 Pandemic had low social health related quality of life, in relation to the other domains. Female, single, patients who were living with their family, and are at stage 2 of clinical staging have better adherence to antiretroviral therapy and is directly correlated to better health-related quality of life.