Background and objectives: Vaccination of health providers is one of the priorities in the response to Covid 19. During this pandemic, the relaxation of vaccine licensing procedures has led to scepticism and mistrust among health care providers and the emergence of rumors that are harmful to Covid 19 vaccination, particularly through social networks. The Objective of this study was to identify factors associated with the uptake of the second dose of Sinopharm by health workers in Koumpentoum health district. Methodology: This was a cross-sectional, descriptive and analytical survey. We conducted a descriptive and analytical study that explored the knowledge, attitudes and practices and acceptability of Covid 19 vaccination by health workers in Koumpentoum health district. Multiple logistic regression was used to identify factors associated with taking the second Sinopharm dose. . Results: In total, we had (168) respondents of whom (59.95%) were women. The mean age was (37.05 ±9.76) years and the median (35) years. Almost all of them, (85.71%), were living with a partner. Unskilled workers represented (74.4%) of respondents. The average length of professional experience was (8.51 ± 5.81) years with median of (7) years. Frequence of co-morbidities was (8.93%), this of the Covid 19 (10.12%) and this of adverse events (16.67%). The second dose coverage of Sinopharm was (82.74%) and the statically and significantly associated factors were age > (35 years (ORa = 4.51 [1.71-11.91]; p = 0.0023), living with a partner (ORa = 4.11 [1.36-12.45]; p = 0.0123) and work experience > (5) years (ORa = 3.15 [1.01-9.08]; p = 0.0321). Conclusions: Factors related to vaccination of health workers against Covid 19 in Koumpentoum district are age, marital status and work experience. Awareness raising and vaccination of young health workers should be a prerequisite for the plan to revive and intensify vaccination against Covid 19.