Background:
Our ability to deal with _Aedes_ mosquito-borne arboviral outbreaks in Africa is still limited._ _Thus, we assessed the risk of transmission arboviruses (e.g., dengue and yellow fever) and _Aedes aegypti_ susceptibility to insecticides and breeding eco-bio-social determinants in disease foci in Côte d’Ivoire.

Methods:
We sampled _Ae. aegypti_ larvae and breeding sites, and household socio-ecological data in arboviral foci in Côte d’Ivoire from June to December 2020. We collected Aedes mosquito samples in two rubber tree areas (Koffikro and Samo), two oil palm areas (Ehania, and Agbaou), and two urban neighbourhoods (Bingerville and Cocody). _Aedes_ larval indices (container index: CI, household index: HI and Breteau index: BI) were determined. Moreover, we tested _Ae. aegypti_ larvae and adults against insecticides (DDT and deltamethrin), and recorded the mortality.

Results:
The most productive _Ae. aegypti_ breeding sites were tyres, discarded cans, water storage containers and rubber latex collection cups. _Stegomyia_ indices were highest in urban areas, followed by rubber areas and oil palm areas, with HI of 98.3, 81.2 and 67.82 CI of 69.7, 57.3 and 29.5, and BI of 99.7, 65.9 and 13.8, respectively. _Ae. aegypti_ showed possible resistance to deltamethrin (mortality: 87,3-90.8%) rubber and oil palm areas, and resistance to DDT (mortality: 57,3-60.1%) in urban neighbourhoods and permethrin (mortality: 79.5-85.4%) in rubber and oil palm areas._ Ae. aegypti_ larval infestation was correlated with complex community behaviours, including water storage practices and solid waste management. _Ae. aegypti_ breeding sites’ positivity was associated with unmanaged solid waste, water supply interruptions, water storage duration and insecticide-susceptibility status.

Conclusions:
In Côte d’Ivoire, _Ae. aegypti_ larval indices and arbovirus transmission risk were correlated with socio-ecological factors and insecticide-resistance level. Integrated community-based vector control is recommended.