Malaria in pregnancy (MiP) is a major health problem, according to World Health Organization in 2020 there were an estimated 33.8 million pregnancies, 34% (11.6 million) of which were exposed to malaria infection.(World Health Organization 2021). Moreover, it contributes to devastating health outcomes that may end up in a medical emergency ('Management of malaria in pregnancy : Indian Journal of Medical Research' 2022).The progression towards scaling up intermitted preventive treatment in pregnancy (IPTp) uptake remains slow relative to other MiP interventions. Preventive strategies and good quality case management are the starting point for controlling the malaria burden. The objective of this study is to review the available knowledge on the main contextual factors of a direct impact on the uptake of IPTp among pregnant women globally, as well as to address the gaps in the existing literature. Methods: A comprehensive literature search was carried out from May to June 2022 on the following online electronic databases; PUBMED, Scopus, Web of Science, EBSCO, and Medline. Sixty-six out of 4210 screened studies addressing the factors that influence the uptake were included. Two independent reviewers investigated the studies for eligibility. Factors that affect the uptake were conceptually analyzed using the socioecological model. Results: It was observed from the literature that there are still low levels of awareness and knowledge among pregnant women regarding IPTp importance, this emphasizes the importance of womens empowerment for health-seeking behavior. The availability, accessibility, and affordability of IPTp pose a persistent challenge that impedes governments from achieving the recommended coverage target. Additionally, Health care workers showed inconsistency while delivering IPTp to women and faced difficulties regarding their working conditions. Conclusions: From a public health perspective policymakers must address health system obstacles that hinder IPTp implementation from being delivered and utilized by pregnant women.